Dennis Chang

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MSc University of Sydney
PhD in Pharmacology, 1998, The University of Sydney
Dennis

Dennis Chang is a Professor of Pharmacology and leader of NICM's Healthy Hearts research program. Over the last 10 years he has developed a strong research agenda in the area of clinical and pharmacological studies of Chinese herbal medicine at NICM and Western Sydney University.

Professor Chang is a chief investigator for a number of significant clinical trials to evaluate complementary medicine interventions (herbal medicine, yoga and Tai Chi) for the treatment of dementia, mild cognitive impairment, coronary heart disease, metabolic syndrome and type 2 diabetes.

He has also led multiple laboratory-based pharmacological studies of herbal medicines to evaluate their pharmacokinetic/bioavailability profiles and mechanisms of action underlying the neuro and cardiac-protective effects of these medicines using a range of in vitro and in vivo models.

Professor Chang has attracted significant research funding from various external funding agencies, governments and industry, and from internal sources totalling over $6M. His research has been published in a broad range of high-quality peer-reviewed journals such as Cochrane Systematic Review (IF:6.032), Journal of Translational Medicine (IF:3.93), Clinical Pharmacology and Therapeutics (IF:7.093), British Journal of Pharmacology (IF:4.842), and Drug (IF4.343).

Professor Chang has a significant involvement in the strategic planning and development of NICM. He has also made exceptional contributions to the development of national and international research collaborations and has attracted partnerships with prestigious international and national universities, research organisations and pharmaceutical/herbal medicine industry.

Areas of Research/Teaching expertise

  • Pharmacology
  • Physiology and Pathophysiology
  • Pharmacokinetics/bioavailability
  • Clinical trials
  • Dementia and cognitive impairment
  • Diabetes and Metabolic disease

Awards and recognition

  • Visiting Professor, Guangzhou Medical University
  • Coordinator of the South Pacific Chapter of the Consortium for Globalisation of Chinese Medicine
  • Australian Postgraduate Award 1993-1995

Grants/ Projects

Professor Chang's research has been supported by numerous external funding agencies including federal and state governments, NHMRC, local and international industry, and professional associations. Over the last five years he has attracted eight successful external research grants totalling $4.7 million. 

See a full list of past and current projects.(opens in a new window)

Publications

Books / Book Chapters

Chang D, Steiner G, Ghosh, Bensoussan A,  2017, Vitamins and complementary therapies used to treat Alzheimer's disease in Dementia, In: Ames, D., Burns, A., O'Brien J.T. (Eds.), Dementia, Vol. 5, CRC Press, Boca Raton, FL, United States.

Nammi S, Sun YT, Chang D. Effects of ginger on metabolic syndrome: A review of evidence. In: Ghosh D, Bagchi D, Konishi T, editors. Clinical aspects of functional foods and neutraceuticals. Boca Raton, FL: CRC Press; 2015. p. 381-98.

Chang D, Colagiuri B, Luo R. Chinese medicine used to treat dementia. In: Stough CK, Scholey AB, editors. Advances in natural medicines, nutraceuticals and neurocognition. Boca Raton, Fla.: CRC Press; 2013. p. 205-23.

Doran C, Chang D, Kiat H, Bensoussan A. Review of economic methods used in complementary medicine: An international reader. In: Adams J, Andrews G, Barnes J, Broom A, Magin P, editors. Traditional, complementary and integrative medicine. United Kingdom: Palgrave MacMillan UK - Academic; 2012. p. 245-53.

Chang DH, Nammi S, Grant SJ. Traditional understanding, modern science and usage of herbal medicine for diabetes. In: Ghosh D, Das S, Bagchi D, Smarta RB, editors. Innovation in healthy and functional foods. Boca Raton, FL CRC Press 2012. p. 455-74.

Chang D, Ghosh D, Bensoussan A. Vitamins and complementary therapies used to treat Alzheimer's disease. In: O'Brien J, Ames D, Burns A, editors. Dementia. 4th ed. London: Hodder Arnold; 2010.

Liang H, Chang D. Cancer clinical trials on Chinese medicine. In: Cho WCS, editor. Supportive cancer care with Chinese medicine. Dordrecht; London Springer Publishing; 2009.

Chan D, Ong B, Chang D. Polypharmacy and adverse drug reaction. In: Chan DKY, Forsyth D, editors. Chan's practical geriatrics Brookvale, NSW: BA Printing & Publishing Services; 2006.

Munroe M, Koyyalamudi S, Bensoussan A, Khoo CS, Chang D. Validation of the key components of the herbal formulation for relief of irritable bowel syndrome. Campbelltown, NSW: University of Western Sydney; 2004.

Mather L, Chang D, 1999, Clinical pharmacology of local anaesthetic agents. In: Regional Anaesthesia, Tiengo, Paladini & Rawal (eds.), Milan: Springer-Verlag Italia Srl. pp. 91-111. Munroe.

Journal Articles

2017

Steiner, G.Z., Mathersul, D.C., MacMillan, F., Camfield, D.A., Klupp, N.L., Seto, S., Huang, Y., Hohenberg, M.I., Chang, D.H., 2017. A systematic review of intervention studies examining nutritional and herbal therapies for mild cognitive impairment and dementia using neuroimaging methods: study characteristics and intervention efficacy. Evidence-Based Complementary and Alternative Medicine. Volume 2017 (2017), Article ID 6083629, 21 pages, https://doi.org/10.1155/2017/6083629

Seto, S.W., Chang, D.H., Ko, W.M., Zhou, X., Kiat, H., Bensoussan, A., Lee, S.M.Y., Hoi, M.P.M., Steiner, G.Z., Liu, J.X., 2017. Sailuotong prevents hydrogen peroxide (H202)-induced injury in EA.hy926 cells. International Journal of Molecular Sciences, 18, 95. DOI: 10.3390/ijms18010095.

2016

Dennis Chang, Jianxun Liu, Kellie Bilinski, et al., "Herbal Medicine for the Treatment of Vascular Dementia: An Overview of Scientific Evidence," Evidence-Based Complementary and Alternative Medicine, vol. 2016, Article ID 7293626, 15 pages, 2016. DOI:10.1155/2016/7293626.

Zhou X, Naumovski V, Chang D, Li C-G, Kam A, Bensoussan A, Chan K, and Low M, 2016, Synergistic effects of Danshen (Salvia Miltiorrhizae Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) combination in inhibiting inflammation mediators in RAW264.7 cells, 2016, BioMed Research International.

Klupp N, Hosen K, Bensoussan A, Steiner G and Chang D, 2016, A double-blind, randomised, placebo-controlled trial of Ganoderma lucidum for the treatment of cardiovascular risk factors of metabolic syndrome, Scientific Reports, 6:29540, DOI:  10.1038/srep29540.

Zhou X, Seto SW, Chang D, Kiat H, Razmovski-Naumovski V, Chan K and Bensoussan A (2016) Synergistic Effects of Chinese Herbal Medicine: A Comprehensive Review of Methodology and Current Research. Front. Pharmacol. 7:201. DOI: 10.3389/fphar.2016.00201.

Li D, Wang J, Hou J, Fu J, Chang D, Bensoussan A, et al. Ginsenoside Rg1 protects starving H9c2 cells by dissociation of Bcl-2-Beclin1 complex. BMC Complementary and Alternative Medicine. 2016;16(1).

Seto S-W, Chang D, Jenkins A, Bensoussan A, Kiat H. Angiogenesis in Ischemic Stroke and Angiogenic Effects of Chinese Herbal Medicine. Journal of clinical medicine. 2016;5(6):56.

Steiner G, Yeung A, Liu J, Camfield D, De Blasio F, Pipingas A, Scholey A, Stough C, Chang D, 2016, The effect of Sailuotong (SLT) on neurocognitive and cardiovascular function in healthy adults : a randomised, double-blind, placebo controlled crossover pilot trial, BMC Complementary and Alternative Medicine, vol 16, pp 1-13.

2015

Chang D, Steiner G, Yeung A, De Blasio F, Pipingas A, Scholey A, et al. Sailuotong (SLT), a standardised Chinese herbal medicine formula, enhances working memory in healthy adults: a pilot study. Integrative Medicine Research. 2015;4(1):14. DOI: 10.1016/j.imr.2015.04.322.

Seto SW, Yang GY, Kiat H, Bensoussan A, Kwan YW, Chang D. Diabetes Mellitus, cognitive impairment, and traditional Chinese medicine. Int J Endocrinol. 2015;2015:1-14. DOI: 10.1155/2015/810439.

Fan X, Wang J, Hou J, Lin C, Bensoussan A, Chang D, et al. Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway. J Transl Med. 2015;13(92):1-11. DOI: 10.1186/s12967-015-0450-z.

van der Kooy F, Yergey A, Venkataya B, Pearson J, Torres A, Li CG, et al. Sensitivity of NMR-based metabolomics in drug discovery from medicinal plants. Eur J Med Plants. 2015;5(2):191-203. DOI: 10.9734/EJMP/2015/13747.

Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, et al. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors (Review). Cochrane DB Syst Rev. 2015;2015(2):1-54. DOI: 10.1002/14651858.CD007259.pub2.

Yeung A, Chang D, Bensoussan A, Kiat H, 2015, Yoga and Cardiac Rehabilitation – A Brief Review of Evidence. J Yoga Phys Ther 5: 207. doi:10.4172/2157-7595.1000207.

Seto S, Kiat H, Lee S, Bensoussan A, Sun Y, Hoi M, Chang D, 2015, Zebrafish models of cardiovascular diseases and their applications in herbal medicine research, European Journal of Pharmacology, vol 768, pp 77-86.

Bensoussan A, Lee S, Murray C, Bourchier S, Van Der Kooy F, Pearson J, Liu J, Chang D, Khoo C, 2015, Choosing chemical markers for quality assurance of complex herbal medicines : development and application of the Herb MaRS criteria, Clinical Pharmacology and Therapeutics, vol 97, no 6, pp 628-640

2014

Zhang Y, Lin L, Ren C, Lin C, Liu J, Chang D, Bensoussan A, 2014, Pharmacokinetics and brain distribution of ginkgolides after administration of Sai-Luo-Tong, Modernization of Traditional Chinese Medicine and Materia Medica, vol 16, no 7, pp 1458-1464.

Yao M, Zhang P, Song W, Xu L, Bensoussan A, Chang D, Liu J, 2014, Effect of Tongluo Qingnao injection on glutamate and GABA in cerebral microdialysis samples of ischemia/reperfusion rats, Chinese Journal of Experimental Traditional Medical Formulae, vol 20, no 12, pp 136-140.

Yeung A, Kiat H, Denniss A, Cheema B, Bensoussan A, Machliss B, Colagiuri B, Chang D, 2014, Randomised controlled trial of a 12 week yoga intervention on negative affective states, cardiovascular and cognitive function in post-cardiac rehabilitation patients, BMC Complementary and Alternative Medicine, vol 14.

Chang D, Bensoussan A. Pharmacokinetics and brain distribution of ginkgolides after administration of Sai-Lao-Tong. Modernization of Traditional Medicine and Materia Materia. 2014;16(7):1458-64. DOI: 10.11842/wst.2014.07.003.

2013

Jelinek HF, Huang ZQ, Khandoker AH, Chang D, Kiat H. Cardiac rehabilitation outcomes following a 6-week program of PCI and CABG patients. Front Physiol. 2013;4:1-7. DOI: 10.3389/fphys.2013.00302.

Asamoah S, Siegler J, Chang D, Scholey A, Yeung A, Cheema BS. Effect of aerobic training on cognitive function and arterial stiffness in sedentary young adults: A pilot randomized controlled trial. Physiology Journal. 2013;2013(2013):1-9. DOI: 10.1155/2013/847325.

Cao H, Wang Y, Chang D, Zhou L, Liu J. Acupuncture for vascular mild cognitive impairment: A systematic review of randomised controlled trials. Acupunct Med. 2013. DOI: 10.1136/acupmed-2013-010363.

Grant SJ, Schnyer RN, Fahey P, Chang DH, Bensoussan A. Interrater reliability of Chinese medicine diagnosis in people with prediabetes Evid-Based Compl Alt. 2013;2013:1-8. DOI: 10.1155/2013/710892.

Grant SJ, Chang DH, Liu JX, Wong V, Bensoussan A, Kiat H. Chinese herbal medicine for impaired glucose tolerance: A randomized placebo controlled trial. BMC Complem Altern M. 2013;13(1):104-13. DOI: 10.1186/1472-6882-13-104.

Cheema B, Houridis A, Busch L, Raschke-Cheema V, Melville G, Marshall P, Chang D, Machliss B, Lonsdale C, Bowman J, Colagiuri B, Effect of an office worksite-based yoga program on heart rate variability: outcomes of a randomized controlled trial, BMC Complem Altern Med. 2013:13(82):1-10.

Tan X, Tan D, Brown L, Yang D, Zhu L, Chen Y, et al. Isolation and purification of four bioactive constituents from Alpinia Officinarum Hance utilizing high-speed counter-current chromatography J Liq Chromotogr R T. 2013;36(10):1355-65. DOI: 10.1080/10826076.2012.691436.

2012

Tan X, Tan D, Brown L, Yang D, Zhu L, Chen Y, et al. Isolation and purification of four bioactive constituents from Alpinia Officinarum Hance utilizing high-speed counter-current chromatography J Liq Chromotogr R T. 2012;36(10):1355-65. DOI: 10.1080/10826076.2012.691436.

Stough CK, Pase MP, Cropley V, Myers S, Nolidin K, King R, Camfield D, Wesnes K, Pipingas A, Croft K, Chang D, Scholey A. A randomized controlled trial investigating the effect of Pycnogenol and Bacopa CDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning in cognitively healthy elderly people: The Australian Research Council Longevity Intervention (ARCLI) study protocol (ANZCTR12611000487910). Nutr J. 2012;11(1):11-20. DOI: 10.1186/1475-2891-11-11.

Grant SJ, Bin YS, Yu SB, Kiat H, Chang DH. The use of complementary and alternative medicine by people with cardiovascular disease: A systematic review. BMC Public Health. 2012;12(4):299-318. DOI: 10.1186/1471-2458-12-299
Melville GW, Chang D, Colagiuri B, Marshall PW, Cheema BS. Fifteen minutes of chair-based yoga postures or guided meditation performed in the office can elicit a relaxation response. Evid-Based Compl Alt. 2012;2012:501986-95. DOI: 10.1155/2012/501986.

2011

Cheema BS, Marshall PW, Chang D, Colagiuri B, Machliss B. Effect of an office worksite-based yoga program on heart rate variability: A randomized controlled trial. BMC Public Health. 2011;11(1):578-83. DOI: 10.1186 /1471-2458-11- 578.

Kiat H, Bin Y, Grant S, Chang D. Complementary medicine use in cardiovascular disease: A clinician's viewpoint. Med J Australia. 2011;195(11):654-6. DOI: 10.5694/mja10.10976.

Cheema BS, Marshall PW, Chang D, Colagiuri B, Machliss B. Effect of an office worksite-based yoga program on heart rate variability: A randomized controlled trial. BMC Public Health. 2011;11(1):578-83. DOI: 10.1186 /1471-2458-11- 578.

2010

Doran CM, Chang DH, Kiat H, Bensoussan A. Review of economic methods used in complementary medicine. J Altern Complem Med. 2010;16(5):591-5. DOI: 10.1089=acm.2008.0404.

Gray MJ, Chang D, Zhang Y, Liu J, Bensoussan A. Development of liquid chromatography/mass spectrometry methods for the quantitative analysis of herbal medicine in biological fluids: A review. Biomed Chromatogr. 2010;24(1):91-103. DOI: 10.1002/bmc.1287.

2009

Grant S, Bensoussan A, Chang D, Kiat H, Klupp N, Liu J, Li X. Chinese herbal medicines for people with impaired glucose tolerance or impaired fasting blood glucose. Cochrane Database of Systematic Reviews. 2009(4). DOI: 10.1002/14651858.CD006690.pub2.

2008

Klupp NL, Chang D, Hawke F, Kiat H, Grant SJ, Bensoussan A. Ganoderma lucidum for the treatment of cardiovascular risk factors. Cochrane Database of Systematic Reviews. 2008(3). DOI: 10.1002/14651858.CD007259.

Wang JN, Liu JX, Chang D, Bensoussan A. Pharmaokinetic study of detecting medicinal ingredients of traditional Chinese medicines in different extract base. Mode Tradit Chin Med Mater Med. 2008;10(6):32-6.

2007

Grant S, Bensoussan A, Chang D, Kiat H, Klupp N, Liu J. Chinese herbal medicines for people with impaired glucose tolerance or impaired fasting blood glucose (Protocol). Cochrane Database of Systematic Reviews. 2007(4). DOI: 10.1002/14651858.CD006690.pub2.

2006

Liu J, Chang D. Vascular Dementia. J Complement Med. 2006; 5(2): Available from: http://search.informit.com.au/documentSummary;dn=122790687804703;res=IELHEA.

2004

Mather L, Duke C, Ladd L, Copeland S, Gallagher G, Chang D. Direct cardiac effects of coronary site-directed thiopental and its enantiomers. Anesthesiology. 2004;101(2):354-64. DOI: 10.1097/00000542-200408000-00016.

Mather L, Ladd L, Copeland S, Chang D. Effects of imposed acid–base derangement on the cardiovascular effects and pharmacokinetics of bupivacaine and thiopental. Anesthesiology. 2004;100(6):1457-68. DOI: 10.1097/00000542-200406000-00018.

2002

Ladd L, Chang D, Wilson K, Copeland S, Plummer J, Mather L. Effects of CNS site-directed carotid arterial infusions of bupivacaine, levobupivacaine, and ropivacaine in sheep. Anesthesiology. 2002;97(2):418-28. DOI: 10.1097/00000542-200208000-00020.

2001

Mather LE, Chang DH. Cardiotoxicity with modern local anaesthetics: Is there a safer choice? Drugs. 2001;61(3):333-42.

Heinke MY, Yao M, Chang D, Einstein R, dos Remedios CG. Apoptosis of ventricular and atrial myocytes from pacing-induced canine heart failure. Cardiovasc Res. 2001 January 1, 2001;49(1):127-34. DOI: 10.1016/s0008-6363(00)00242-x.

Chang D, Ladd L, Copeland S, Iglesias M, Plummer J, Mather L. Direct cardiac effects of intracoronary bupivacaine, levobupivacaine and ropivacaine in the sheep. Br J Pharmacol. 2001;132(3):649-58. DOI: 10.1038/sj.bjp.0703858.

2000 and prior

Chang DHT, Ladd LA, Wilson KA, Gelgor L, Mather LE. Tolerability of large-dose intravenous levobupivacaine in sheep. Anest Analg. 2000 September 1, 2000;91(3):671-9.

Heinke M, Wheeler C, Yan J, Amin V, Chang D, Einstein E, Dunn M, dos Remedios C, 1999, Changes in myocardial protein expression in pacing-induced canine heart failure. Electrophoresis. 20(10):2086-93.

Heinke MY, Wheeler CH, Chang D, Einstein R, Drake-Holland A, Dunn MJ, et al. Protein changes observed in pacing-induced heart failure using two-dimensional electrophoresis. Electrophoresis. 1998;19:2021-3.

Chang D, Einstein R, 1996, Changes in cardiovascular responsiveness of dopexamine and function of 1- and 2-adrenoceptor after the chronic treatment of adrenoceptor antagonists and agonists. J. Autonomic Pharmacology, 16, 269-279.

Einstein R, Abdul-Hussein N, Wong T, Chang D, Matthews R, Richardson D, 1994, Cardiovascular actions of dopexamine in anaesthetized and conscious dogs. British Journal Pharmacology, 11, 199-204.

Conferences

Seto S, Jenkins A, Kiat H, Bensoussan A, Liu J and Chang D, 2016, Protective Effects of a Standardised Herbal Formulation, Sailuotong, on Hydrogen Peroxide (H2O2)-induced Damage in EA.hy926 Cells. The International Congress on Integrative Medicine and Health (Las Vegas, USA).

Steiner, G.Z., Yeung A., Camfield, D.A., Pipingas A., Scholey, A.B., Stough, C., Chang, D., 2015. A pilot study on Sailuotong, a Chinese herbal medicine formula, for cognition and brain activity. Advances in Integrative Medicine, 2,115. doi:10.1016/j.aimed.2015.07.003.

Chang, D., Steiner, G.Z., Yeung, A., De Blasio, F.M., Pipingas, A., Scholey, A.B., Stough, C., 2015. Sailuotong (SLT), a standardised Chinese herbal medicine formula, enhances working memory in healthy adults: a pilot study. Integrative Medicine Research, 4, s14. doi: 10.1016/j.imr.2015.04.322.

Liu J, Chang D, 2015, Development of evidence-based herbal medicine for vascular dementia, NICM National Symposium on Neurocognition and Dementia (Sydney, Australia).

Steiner, G.Z., Yeung, A., Camfield, D.A., De Blasio, F.M., Pipingas, A., Scholey,A.B., Stough, C., Chang, D.H., 2014. The effect of a standardised Chineseherbal medicine formula (Sailuotong) on N1, PN, P2, MMN, P3a, and P3b amplitudes: a pilot study. Front. Hum. Neurosci. Conference Abstract: Australasian Society for Psychophysiology, Inc. doi: 10.3389/conf.fnhum.2014.216.00025.

Grant S, Chang D, Schnyer R, Fahey P, Bensoussan 2014, Improving inter-rater reliability of TCM diagnosis of prediabetes through the use of biomarkers, International Congress on Integrative Medicine and Health (Miami, USA).

Chang D, 2014, The use and regulation of Chinese medicine in Australia, International Congress on Integrative Medicine and Health (Miami, USA).

Chang D, Low M, Khoo C, Li C, Chan K, Bensoussan A, 2014, Pharmacokinetic Study of a Standardised Herbal Extract of Diospyros kaki Leaves in Rats Proceedings of the 13th Meeting of Consortium for Globalization of Chinese Medicine (Beijing, China).

Chang D, 2013, A Multicentre, Randomised, Double-Blind, Placebo Controlled Trial to Evaluate the Effectiveness and Safety of a Standardised Chinese Herbal Medicine for VaD and AD with Cerebrovascular Disease, The 2013 Annual conference of the International Society for Intelligence Research (Swinburne University, Melbourne).

Yeung A, Colagiuri B, Camfield D, Scholey A,  Chang D, 2013, Effects of a Standardised Herbal Formulation (SLT) on Neurocognitive Function in Healthy Volunteers – a pilot study, Proceedings of the 12th Meeting of Consortium for Globalization of Chinese Medicine (Graz, Austria).

Chang D, 2012, Current status of SLT clinical study in Australia, China- Australia Chinese Medicine international Cooperation and Promotion Forum (Beijing, China).

Chang D, 2012, The Use of Herbal Medicine as Therapeutics in Dementia, the 6th International Niigata Symposium on Diet and Health (Niigata, Japan).

Chang D, 2012, Chinese Herbal Medicine for Vascular Dementia, Swinburne brain health conference (Melbourne Australia).

Melville G, Chang D, Colagiuri B, Marshall P,  Cheema B, 2012, Fifteen minutes of yoga postures or guided meditation in the office can elicit psychological and physiological relaxation. Proceedings of International Research Congress on Integrative Medicine and Health (Portland, USA).

Chang D, 2012, Cardiac Rehabilitation Progam: benefits and challenges, the 3rd Guangzhou Medical University Cardiology Conference (Guangzhou, China).

Melville GW, Chang D, Colagiuri B, Marshall P, Cheema B, 2011, Fifteen minutes of yoga postures or guided meditation in the office can elicit psychological and physiological relaxation.  Journal of Science and Medicine in Sport, 14(7):73 (supplement).

Chang D, 2011, The use of complementary medicine in cardiac rehabilitation, Annual Scientific Symposium, Guangdong Association of Pharmacology (Guangzhou, China).

Chang D, Liu J, Li X, Liu JG, Chan D, Bensoussan, A,  2011, Development of an evidence-baseed herbal medicine for vascular dementia. The 4th AACBS Scientific Meeting (Sydney, Australia).

Chang D, Dedov, V, Liu J, 2011, Inhibitory Effects of Sailuotong (SLT) on NMDA-dependent Ca2+ Influx. Proceedings of  the 6th International Congress on Complementary Medicine Research (Chengdu, China).

Chang D, 2011, Recent development of complementary medicine research in Australia. 10th Meeting of Consortium for Globalization of Chinese Medicine (Shanghai, China).

Chang D, 2011, The use of complementary medicine in the prevention of diabetes, 2nd Annual Australian Obesity Summit (Sydney, Australia).

Dedov V, Chang D, Liu J, 2010, Neuroprotective effect of Sailuotong mediated by inhibition of NMDA-dependent Ca2+ influx, Proceedings of the 9th Meeting of Consortium for Globalization of Chinese Medicine (Hong Kong).

Chang D, 2009, Development of evidence-based complementary medicine: an Australian perspective, Annual Research Symposium, InternationalSociety for Chinese Medicine (ISCM), (Macao, China).

Dedov V, Chang D, Liu J, Sucher N, 2009, Effect of Wei Nao Kang, a herbal formula for vascular dementia, on the activity of cytochrome P450 isozymes. Proceedings of the 8th Meeting of Consortium for Globalization of Chinese Medicine (Nottingham, UK).

Grant S, Bensoussan A, Chang D, Kiat H, Klupp N, Liu J, 2009, A systematic Review of Chinese Herbal Medicine for the Treatment of Prediabetes. Proceedings of 2009 Australasian Acupuncture and Chinese Medicine Annual Conference, 21. (Melbourne, Australia).

Chang D, Benoussan A, 2008, Development of a National Approach in Traditional Chinese Medicine Research. Conference Proceedings of the 7th meeting of the Consortium for Globalization of Chinese Medicine, 23. (Taipei, Taiwan).

Bensoussan A, Chang D, 2008, Database of Chinese Herbal Medicine Toxicology. Conference Proceedings of the 7th meeting of the Consortium for Globalization of Chinese Medicine, 34. (Taipei, Taiwan).

Chang D,  Liu JX, Wang JN, Li X, Liu JG, Chan D, Bensoussan A, 2008, Development of an Evidence-based Herbal Medicine for the Management of Vascular Dementia. Canadian Journal of Clinical Pharmacology, 15(3), e455 (presented at IX World Congress on Clinical Pharmacology and Therapeutics, Quebec, Canada,  2008).

Klupp N, Chang D, Bensoussan A, Kiat H, 2008, Systematic review of the effectiveness of Ganoderma lucidum for treatment of cardiovascular risk factors. Proceedings of 3rd International Congress on Complementary Medicine Research, 10.

Liu J, Chang D, Benoussan A, Chan D, Chang S, 2008, Application of the General Health Status Questionnaire SF36 to Patients with Vascular Dementia: Initial Validation and Validation as a Measure of Change. Proceedings of 3rd International Congress on Complementary Medicine Research, 11.

Grant S, Bensoussan A, Chang D, Klupp N, Yanke A, Liu JP, Kiat H, 2008, The effectiveness of Chinese herbal medicine in the treatment of impaired glucose tolerance: a systemic review. Proceedings of 3rd International Congress on Complementary Medicine Research, 121.

Liu J, Chang D, Chan D, Liu JX, Bensoussan A, 2007, A randomised placebo-controlled clinical trial of a Chinese herbal medicine for the treatment of vascular dementia. Proceedings of 2nd International Congress for Complementary Medicine Research, Munich, May 2007.

Chang D, 2006, Complementary Medicine in Dementia: an Overview of the Scientific Evidence. Proceedings of Better Practice Sydney 2006, Sydney, August.

Bensoussan A, Drew AK, Whyte IM, Dawson AH, Myers SP, Zhu X, Chang D, Wu S, 2002, Development of a Chinese herbal medicine toxicology database. Conference Proceedings of the International Conference on the Integration of Chinese Medicine and Western Medicine: A Focus on Women's Health, 15.

Chang D, Ladd LA, Gallagher G, Wilson K, Copeland S, Mather LE, 2001, Close coronary arterial injection studies of thiopentone enantiomers in the sheep. Proceeding of ASCEPT, 9, 33.

Chang D, Ladd LA, Copeland S, Wilson K, Mather LE, 2000, Direct cardiac effects of intracoronary Bupivacaine, levobupivacaine, and ropivacaine in sheep. Proceeding of ASCEPT, 8, 3.

Chang D, Mather LE, 1999, Intravenous tolerance of levobupivacaine in sheep. Conference Proceedings of 8th Southeast Asia-Western Pacific Regional Meeting of Pharmacologists, 136.

Chang D, Einstein R, 1999, Pacing-induced heart failure and muscarinic receptors. Journal of Molecular and Cellular Cardiology. 31: A1.

Chang D, Ladd LA, Copeland SE, Gelgor L, Iglesias M, Wilson K, Mather LE, 1998, Effects of acid-base changes on bupivacaine-induced toxicity.  Proceedings of ASCEPT, 5, 119.

Chang D, Mather LE, Ladd LA, Copeland SE, Gelgor L, 1997, Effects of high doses of levobupivacaine on the cardiovascular and central nervous systems.  Proceedings of ASCEPT, 4, 76.

Chang D, Einstein R, 1996, Impaired vasodilator response to A23187 in pacing-induced heart failure. Proceedings of 6th International Congress on Cardiovascular Pharmacotherapy, A7.

Chang D, Einstein R, 1996, Reduced of carbachol-induced negative inotropic response in cardiac muscle from dogs with pacing-induced heart failure. Proceedings of 6th International Congress on Cardiovascular Pharmacotherapy, A7.

Chang D, Sanders N, Einstein R, 1996, Reduced in vivo cardiovascular responses to endothelin-1 in pacing-induced heart failure. Proceedings of ASCEPT, 3, 36.

Sanders N, Chang D, Einstein R, 1996, Reduced in vitro vascular responsiveness to endothelin in pacing-induced heart failure.  Proceedings of ASCEPT, 3, 99.

Chang D, Einstein R, 1995, Decreased cardiac muscarinic receptor responsiveness in pacing-induced heart failure. Proceedings of ASCEPT, 2, 150.

Chang D, Einstein R, 1993, Selective beta2-adrenoceptor up-regulation by beta1-adrenoceptor antagonist treatment in anaesthetised dogs. Clin. Exp. Pharmacol. Phyisol., Suppl 1, 14.

Einstein R, Chang D, 1993, Changes in canine cardiovascular beta-adrenoceptor responsiveness induced by chronic beta-adrenoceptor agonist treatment. Clin. Exp. Pharmacol. Phyisol., Suppl 1, 22.