Sai Seto

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BSc(Hons) in Pharmacology, The University of Liverpool (UK), 2004Sai Seto
PhD in Pharmacology, The Chinese University of Hong Kong, 2008

Dr. Sai Wang Seto completed his PhD in Cardiovascular Pharmacology at the Chinese University of Hong Kong in 2008. His thesis project focused on the evaluation of the modulatory effects of HMG CoA reductase inhibitor on the vascular reactivity. Sai received his postdoctoral training from the Department of Physiology of the Royal College of Surgeons in Ireland focusing on blood pressure regulation and vascular/smooth muscle physiology using both in vitro and in vivo models. Before joining the NICM, Sai worked as a Senior Scientist in the Queensland Research Centre for Peripheral Vascular Disease, James Cook University and was a recipient of the National Health and Medical Research Council Research Fellowship and National Heart Foundation Fellowship. 


Sai has strong and continuing interest in cardiovascular physiology and pharmacology research aiming at identifying new treatments for cardiovascular diseases such as hypertension, atherosclerosis, aortic aneurysm and stroke. During his PhD training, Sai participated in several pharmacological studies on TMC using both in vitro and in vivo models. Over the last 5 years, he has been actively involved in numerous collaborative projects on herbal medicine with The Chinese University of Hong Kong, The Hong Kong Polytechnic University and Macau University. Working with A/Prof. Chang, Sai is responsible for the development of pre-clinical in vitro and in vivo models to evaluate the underlying mechanism of actions of TCM for cardiovascular diseases and understanding of the synergistic effects of herbal medicine.

Memberships and Services:

  • Member of British Pharmacological Society
  • Member of Australia Vascular Biology Society
  • Member of NHMRC Research Translation Faculty
  • Development Team Member of the National Heart Foundation Queensland Cardiovascular Research Network
  • Reviewer of Pharmaceutical Biology
  • Guest Lecturer – College of Arts, Society and Education, James Cook University
  • Visiting Research Fellow – School of Biomedical Sciences, The Chinese University of Hong Kong

Grants / Projects 

Dr Seto's research has been supported by numerous external funding agencies including NHMRC and industry.

See a full list of past and current projects(opens in a new window).

Publications

Journals

2015

Seto SW, Yang GY, Kiat H, Bensoussan A, Kwan YW, Chang D. Diabetes Mellitus, cognitive impairment, and traditional Chinese medicine. Int J Endocrinol. 2015;2015:1-14. DOI: 10.1155/2015/810439.

Wang Y, Emeto T, Lee J, Marshman L, Moran C, Seto S, et al. Mouse models of intracranial aneurysm. Brain Pathology. 2015;25(3):237-247.

Krishna SM, Seto SW, Jose RJ, Biros E, Moran CS, Wang Y, et al. A peptide antagonist of thrombospondin-1 promotes abdominal aortic aneurysm progression in the angiotensin II-infused apolipoprotein-E-deficient mouse. Arterioscler Thromb Vasc Biol. 2015 35(2):389-98. doi: 10.1161/ATVBAHA.114.304732

Moxon JV, Behl-Gilhotra R, Morton SK, Krishna SM, Seto SW, Biros E, et al. Plasma low-density lipoprotein receptor-related protein 1 concentration is not associated with human abdominal aortic aneurysm presence. European Journal of Vascular and Endovascular Surgery. 2015:1-8. doi: 10.1016/j.ejvs.2015.06.023.

Poon CC, Li RW, Seto SW, Kong SK, Ho HP, Hoi MP, et al. In vitro vitamin K2 and 1α,25-dihydroxyvitamin D3 combination enhances osteoblasts anabolism of diabetic mice. Eur J Pharmacol. 2015;767:30-40. DOI: 10.1016/j.ejphar.2015.09.048

2014

Emeto T, Seto SW, Golledge J. Targets for medical therapy to limit abdominal aortic aneurysm progress. Curr Drug Targets (2014) 15(9): 860-873

Wang Y, Emeto T, Lee J, Marshman L, Moran C, Seto SW, Golledge J. Mouse modes of intracranial aneurysm. Brain Pathology (2014) Accepted Manuscript.

Seto SW, Krishna SM, Moran CS, Liu D, Golledge J. Aliskiren limits abdominal aortic aneurysm, ventricular hypertrophy and atherosclerosis in an apolipoprotein E deficient mouse model. Clin Sci (Lond) (2014) 127(2): 123-34.

Wang Y, Seto SW, Golledge J. Angiotensin II, sympathetic nerve activity and chronic heart failure. Heart Failure Reviews (2014) 19(2): 187-198.

2013

Clancy P, Seto SW, Koblar SA, Golledge J. Role of angiotensin converting enzyme 1/angiotensin II/ angiotensin receptor 1 axis in interstitial collagenase expression in human carotid atheroma. Atherosclerosis (2013) 229(2): 331-337.

Seto SW, Au AL, Poon CC, Zhang Q, Li RW, Yeung JH, Kong SK, Ngai SM, Wan S, Ho HP, Lee SM, Hoi MP, Chan SW, Leung GP, Kwan YW. Aucte simvastatin inhibits KATP channels of porcine coronary artery myocytes. PLOS One (2013) 8(6): e66404

Wang Y, Seto SW, Golledge J. Therapeutic effects of renal denervation on renal failure. Curr Neurovasc Res. (2013) 10(2): 172-184

Seto SW, Krishna S, Yu HY, Liu D, Khosla S, Golledge J. Impaired acetylcholine-induced endothelium-dependent aortic relaxation by caveolin-1 in angiotensin II-infused apolipoprotein-E knockout mice. PLOS One (2013) 8(3): e58481.

2012

Krishna S, Seto SW, Moxon J, Rush C, Walker P, Norman P, Golledge J. Fenofibrate increased high density lipoprotein and sphingosine 1 phosphate concentration limiting abdominal aortic aneurysm progression in a mouse model. American J Pathology (2012) 181(2): 706-718.

2010

Poon CC, Seto SW*, Au AL, Zhang Q, Li RW, Lee WY, Leung GP, Kong SK, Yeung JH, Ngai SM, Ho HP, Lee SM, Chan SW, Kwan YW Mitochondrial monoamine oxidase-A-mediated hydrogen peroxide generation enhances 5-hydroxytryptamine-induced contraction of rat basilar artery. British Journal of Pharmacology (2010) 161(5): 1086-98. (*: Co-first authorship)

Kwok CY, Wong CNY, Yau MYC, Yu PHF, Au ALS, Poon CCW, Seto SW, Lam TY, Kwan YW, Chan SW. Consumption of dried fruit of Crataegus pinnatifida (hawthorn) suppresses high-cholesterol diet-induced hypercholesterolemia in rat. Journal of Functional Foods (2010) 2(3): 179-186

Chan E, Wong CY, Wan CW, Kwok CY, Wu JH, Ng KM, So CH, Au AL, Poon CC, Seto SW, Kwan YW, Yu PH, Chan SW. Evaluation of anti-oxidant capacity of root of Scutellaria baicalensis Georgi, in comparison with roots of Polygonum multiflorum Thunb and Panax ginseng CA Meyer. American Journal of Chinese Medicine (2010) 38(4): 815-827

Seto SW, Bexis S, McCormick PA, Docherty JR. Actions of thalidomide in producing vascular relaxation. European Journal of Pharmacology (2010) 644(1-3): 113-9

Seto SW & Docherty JR. Effects of T-type calcium channel blockers and thalidomide on contractions of rat vas deferens British Journal of Pharmacology (2010) 159(6): 1211 - 1216

Docherty JR & Seto SW. Actions of verapamil in producing vascular relaxations. Artery Research (2010) 4(4): 176

2009

Zhang M, Chen SL, Seto SW, Kwan YW, Chan SW Correlation of antioxidative properties and vaso-relaxation effects of major active constituents of traditional Chinese medicine. Pharmaceutical Biology (2009) 47(4): 366-371

Seto SW, Lam HY, Lau WS, Au AL, Lam TY, Chim SS, Ngai SM, Chan SW, Leung TY, Yeung JH, Kong SK, Leung GP, Lee SM, Kwan YW Role of monoamine oxidases in the exaggerated 5-hydroxytryptamine-induced tension development of human isolated preeclamptic umbilical artery European Journal of Pharmacology (2009) 605 (1-3): 129–137.

Zhang Y, Hu G, Lin HC, Hong SJ, Deng YH, Tang JY, Seto SW, Kwan YW, Waye MM, Wang YT, Lee SM Radix Astragali extract promotes angiogenesis involving vascular endothelial growth factor receptor-related phosphatidylinositol 3-kinase/Akt-dependent pathway in human endothelial cells Phytotherapy Research (2009) 23(9): 1205 – 1213

Li RW, Seto SW, Au AL, Kwan YW, Chan SW, Lee SM, Tse CM, Leung GP Inhibitory effect of nonsteroidal anti-inflammatory drugs on adenosine transport in vascular smooth muscle cells European Journal of Pharmacology (2009) 612(1-3): 15–20.

Wu JH, Li Q, Wu MY, Guo DJ, Chen HL, Chen SL, Seto SW, Au AL, Poon CC, Leung GP, Lee SM, Kwan YW, Chan SW Formononetin, an isoflavone, relaxes rat isolated aorta through endothelium-dependent and endothelium-independent pathways Journal of Nutritional Biochemistry (2009) 21(7): 613–620.

Lam TY, Seto SW*, Au AL, Poon CC, Li RW, Lam HY, Lau WS, Chan SW, Ngai SM, Leung GP, Lee SM, Tsui SK, Kwan YW Folic acid supplementation modifies beta-adrenoceptor-mediated in vitro lipolysis of obese/diabetic (+db/+db) mice Experimental Biology and Medicine (2009) 234 (9); 1047–1055. (*: Co-first authorship)

Seto SW, Lam TY, Or PM, Lee WY, Au AL, Poon CC, Li RW, Chan SW, Yeung JH, Leung GP, Lee SM, Ngai SM, Kwan YW Folic acid consumption reduces resistin level and restores blunted acetylcholine-induced aortic relaxation in obese/diabetic mice Journal of Nutritional Biochemistry (2009) 21(9); 872-880.

Chu KY, Cheng Q, Chen C, Au LS, Seto SW, Tuo Y, Motin L, Kwan YW, Leung PS Angiotensin II exerts glucose-dependent effects on Kv currents in mouse pancreatic beta-cells via angiotensin II type 2 receptors American Journal of Physiology - Cell Physiology (2009) 298(2); C313.

Hong SJ, Wan JB, Zhang Y, Hu G, Lin HC, Seto SW, Kwan YW, Lin ZX, Wang YT, Lee SM Angiogenic effect of saponin extract from Panax notoginseng on HUVECs in vitro and zebrafish in vivo Phytotherapy Research (2009) 23(5;) 677–686.

Leung GPH, Ho EYW, Li RWS, Seto SW, Kwan YW Diabetes- and hypertension-induced upregulation of concentrative nucleoside transporter-2 in endothelial cells. Journal of Vascular Research (2009) 46; 178.

2008

Seto SW, Lam TY, Tam HL, Au AL, Chan SW, Wu JH, Yu PH, Leung GP, Ngai SM, Yeung JH, Leung PS, Lee SM, Kwan YW Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice Phytomedicine (2008) 16(5); 426–436.

Yang C, Kwan YW, Seto SW, Leung GP Inhibitory effects of epoxyeicosatrienoic acids on volume-activated chloride channels in rat mesenteric arterial smooth muscle Prostaglandins & Other Lipid Mediators (2008) 87(1-4); 62–67.

2007

Seto SW, Au AL, Lam TY, Chim SS, Lee SM, Wan S, Tjiu DC, Shigemura N, Yim AP, Chan SW, Tsui SK, Leung GP, Kwan YW. Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells. Brit. J. Pharmacol. (2007) 151: 987-997.

Seto SW, Lam TY, Leung GP, Au AL, Ngai SM, Chan SW, Kwan YW. Comparison of vascular relaxation, lipolysis and glucose uptake by peroxisome proliferator-activated receptor-gamma activation in +db/+m and +db/+db mice. Eur. J. Pharmacol. (2007) 572: 40-48.

Leung HS, Seto SW, Kwan YW, Leung FP, Au AL, Yung LM, Yao X, Huang Y. Endothelium-independent relaxation to raloxifene in porcine coronary artery. Eur. J. Pharmacol. (2007) 555: 178-184.

Chan YS, Cheng LN, Yu PHF, Seto SW, Kwan YW, Wu JH, Guo DJ, Cheng HL and Chan SW (2007). A scientific review on the therapeutic uses of Arctium lappa extract. Hong Kong Food & Science Technology Association.

2006

Lam FF, Seto SW, Kwan YW, Yeung JH, Chan P. Activation of the iberiotoxin-sensitive BKCa channels by salvianolic acid B of the porcine coronary artery smooth muscle cells. Eur. J. Pharmacol. (2006) 546: 28-35.

Au AL, Seto SW, Chan SW, Chan MS, Kwan YW. Modulation by homocysteine of the iberiotoxin-sensitive, Ca2+ -activated K+ channels of porcine coronary artery smooth muscle cells. Eur. J. Pharmacol. (2006) 546: 109-119.

Lam TY, Seto SW*, Lau YM, Au LS, Kwan YW, Ngai SM, Tsui KW Impairment of the vascular relaxation and differential expression of caveolin-1 of the aorta of diabetic +db/+db mice. Eur. J. Pharmacol. (2006) 546: 134-141. (*: Co-first authorship)

Seto SW, Kwan YW, Ngai SM Modulatory effect of interleukin-1beta on rat isolated basilar artery contraction. Eur. J. Pharmacol. (2006) 531: 238-245.

Seto SW, Ho YY, Hui HN, Au AL, Kwan YW. Contribution of glibenclamide-sensitive, ATP-dependent K+ channel activation to acetophenone analogues-mediated in vitro pulmonary artery relaxation of rat. Life Sci. (2006) 78: 631-639.

2005

Lau YM, Kwan YW, Au LS, Seto SW, Tseung YTS, Chim SCS, Tsui KW and Liu WKK (2005). Receptor Sequence GenBank Accession No. DQ205419 GenBank-National Center for Biotechnology Information United States of America: National Institute of Health, USA.