Srinivas Nammi

Srinivas Nammi

Contact Srinivas

PhD Pharmaceutical Sciences, Andhra University, 2003

Dr Srinivas Nammi has a doctorate in Pharmaceutical Sciences, specialising in Pharmacology. Before joining Western Sydney University as a lecturer in Pharmacology, Dr Nammi worked at the University of Sydney for three years and at the University of Canberra for one year.

Dr Nammi has completed all his academic degrees at Andhra University, in the Faculty of Pharmaceutical Sciences, India. Since completing his PhD in 2003, he has gained extensive postdoctoral experience at the University of Tubingen, Germany and at the University of Manitoba, Canada.

Dr Nammi has worked as an Industrial Pharmacologist for a year where he was closely associated with the establishment of a Pharmacology research laboratory. He has an excellent track record in herbal medicines research and made significant contribution to both basic and applied research related to drug discovery, biological evaluation and mechanistic studies with special focus on metabolic disorders. He has published 42 scientific papers with more than 450 research citations and contributed to over 30 conference abstracts. 

Areas of Research / Teaching Expertise

Dr Srinivas Nammi has over 15 years of experience in pharmacological research in the areas of endocrine and cardiovascular pharmacology through working on various projects in academic and industrial setting with special focus on the cause and treatment of metabolic syndrome and type 2 diabetes. He has a distinguished track record in herbal medicines research and made significant contribution to both basic and applied research related to drug discovery, biological evaluation and mechanistic studies using various pharmacological and molecular biology methods. So far, Dr Nammi has supervised four master student projects, four honours student projects, three advanced student projects, and four summer student projects.

  • Pathophysiological mechanisms and therapeutic interventions involved in:
    Insulin resistance, obesity and type-2 diabetes.
    Beta-cell dysfunction and Diabetes mellitus.
    Glucocorticoid excess and metabolic syndrome with special focus on 11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1).
  • Evaluation and identification of mechanism(s) of action of traditional herbal medicines in the treatment/prevention of:
    Obesity
    Type 2 diabetes and its complications
    Lipid disorders
    Cardiovascular diseases
    Oxidative stress
  • Mechanisms involved in low, moderate and heavy alcohol consumption (prenatal and postnatal) on the development of:
    Fatty Liver Disease
    Metabolic syndrome
    Type 2 diabetes
  • Pharmacokinetics and drug interactions
    Pharmacokinetic evaluation of traditional herbal medicines to discover biologically active compounds for the treatment of metabolic syndrome and type 2 diabetes:
    Drug-drug interactions
    Herb-drug interactions

 Awards and Recognition

  • Sesquicentenary (SESQUI) University of Sydney Postdoctoral Fellowship, Australia 2006-07-07
  • Deutscher Akademischer Austausch Dienst (DAAD) Fellowship, Germany 2003-06-10
  • Council of Scientific and Industrial Research (CSIR) Senior Research Fellowship, India 1999-10-01
  • Best Presentation Award, Seminar on Pharmaceutical Research in the New Millennium , India 2002-05-01
  • Best Paper Award, 52nd Indian Pharmaceutical Congress, India 2000-12-03
  • Graduate Aptitude Test in Engineering (GATE) Fellowship, India 1996-03-31
  • Editorial board member of Journal of Diabetes & Endocrinology
  • Peer reviewer for biomedical journals including Basic & Clinical Pharmacology & Toxicology, BMC Complementary & Alternative Medicine, BMC Pharmacology, Diabetes Technology & Therapeutics, Indian Journal of Pharmacology, Journal of Diabetes
  • Examiner for honours/masters/PhD theses from domestic and overseas universities

Grants / Projects

Dr Nammi's research has been supported by numerous external funding agencies including industry and professional associations.

See a full list of past and current projects(opens in a new window).

Publications

Book Chapters

Nammi S, Sun YT, Chang D. Effects of ginger on metabolic syndrome: A review of evidence. In: Ghosh D, Bagchi D, Konishi T, editors. Clinical aspects of functional foods and neutraceuticals. Boca Raton, FL: CRC Press; 2015. p. 381-98.

Chang DH, Nammi S, Grant SJ. Herbal medicine - Traditional understanding, modern science and usage of herbal medicines for diabetes. In: Ghosh D, Das S, Bagchi D, Smarta RB, editors. Innovation in healthy and functional foods. Boca Raton, FL CRC Press 2012. p. 455-74. ISBN: 9784139862674.

Li G, Li K, Naumovski V, Omar E, Teoh A, Song M, et al. Evaluation of biological activity in quality control of herbal medicines. In: Gupta VK, Tanjela SC, Gupta BD, editors. Comprehensive Bioactive Natural Products: Quality control & standardization. Houston, Texas: Studium Press LLC; 2010.

Journal Articles

2015

Ghelani H, Razmovski-Naumovski V, Kyada AV, Parekh HS, Li GQ, Nammi S. Myoglobin and low density lipoprotein glycation in cardiac complications of diabetes: Current perspectives and therapeutic options. Indian J Med Res. 2015. In Press

Jadeja R, Devkar RV, Nammi S. Hepatoprotective potential of herbal medicine. Evid-Based Compl Alt. [Editorial]. 2015;2015.

Kam A, Li KM, Razmovski-Naumovski V, Nammi S, Chan K, Grau GE, et al. Curcumin reduces tumour necrosis factor-enhanced annexin V-positive microparticle release in human vascular endothelial cells. J Pharm Pharm Sci. 2015;18(4):424-33.

Thounaojam MC, Nammi S, Jadeja R. Natural products for the treatment of obesity, metabolic syndrome, and type 2 diabetes 2014. Evid-Based Compl Alt. [Editorial]. 2015;2015. DOI: 10.1155/2015/392681.

Yang WC, Chang CLT, Li CR, Nammi S, Cho WCS. Complementary and alternative medicine for diabetes 2014. Evid-Based Compl Alt. [Editorial]. 2015;2015. DOI: 10.1155/2015/685248.

2014

Li Y, Tran VH, Kota BP, Nammi S, Duke CC, Roufogalis BD. Preventative effect of Zingiber officinale on insulin resistance in a high-fat high-carbohydrate diet-fed rat model and its mechanism of action. Basic Clin Pharmacol. 2014;115(2):209-15. DOI: 10.1111/bcpt.12196. 

Jadeja R, Devkar RV, Nammi S. Herbal medicines for the treatment of nonalcoholic steatohepatitis: Current scenario and future prospects. Evid-Based Compl Alt. 2014. DOI: 10.1155/2014/648308.

Li Y, Tran VH, Kota BP, Nammi S, Duke CC, Roufogalis BD. Preventative effect of Zingiber officinale on insulin resistance in a high-fat high-carbohydrate diet-fed rat model and its mechanism of action. Basic Clin Pharmacol. 2014;115(2):209-15. DOI: 10.1111/bcpt.12196.

Kam A, Li KM, Razmovski-Naumovski V, Nammi S, Chan K, G.Q. L. Gallic acid protects against endothelial injury by restoring the depletion of DNA methyltransferase 1 and inhibiting proteasome activities. Int J Cardiol. 2014;171(2):231-42. DOI: 10.1016/j.ijcard.2013.12.020.

2013

Yang WC, Nammi S, Jeppesen PB, Cho WCS. Complementary and alternative medicine for diabetes (editorial). Evid-Based Complem Alt 2013;2013. DOI: 10.1155/2013/831068.

Nammi S, Roufogalis BD. Light-to-moderate ethanol feeding augments AMPK-α Phosphorylation and attenuates SREBP-1 expression in the liver of rats. J Pharm Pharm Sci. 2013;16(2):342-51.

Matin A, Doddareddy MR, Gavande N, Nammi S, Groundwater PW, Roubin RH, et al. The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists. Bioorgan Med Chem. 2013;21(3):766-78. DOI: 10.1016/j.bmc.2012.11.040.

Kam A, Li KM, Razmovski-Naumovski V, Nammi S, Shu J, Chan K, et al. A comparative study on the inhibitory effects of different pomegranate parts and their chemical compositions on α-amylase and α-glucosidase. Phytother Res. 2013;27(11):1614–20. DOI: 10.1002/ptr.4913.

Kam A, Li K, M., Razmovski-Naumovski V, Nammi S, Chan K, Li GQ. Variability of the polyphenolic content and antioxidant capacity of methanolic extracts of pomegranate peel. Nat Prod Commun. 2013;8(6):707-10.

2012

Kam A, Li KM, Razmovski-Naumovski V, Nammi S,  Chan K, Li GQ. Combination of TNF-α, homocysteine and adenosine exacerbated cytotoxicity in human cardiovascular and cerebrovascular endothelial cells. Cellular Physiology & Biochemistry 2012; 30: 805-814.

Li GQ, Liew YL, Bridgman KE, Li LY, Narayan I, Nammi S, Huang T, Omar EA. Clinical Herbs. Computer Software. Apple App Store. Vers. XXXX. Elsevier Inc, 2012.

Kam A, Li KM, Razmovski-Naumovski V, Nammi S, Chan K, Li Y, Li GQ. The protective effects of natural products on blood-brain barrier breakdown. Current Medicinal Chemistry 2012; 19: 1830-1845.

Li XH, McGrath K, Nammi S, Heather AK, Roufogalis BD. Attenuation of liver pro-inflammatory responses by Zingiber officinale via inhibition of NF-kappaB activation in high-fat diet-fed rats. Basic & Clinical Pharmacology & Toxicology 2012; 110: 238-244

2010

Omar, E., Kam, A., Alqahtani, A., Li, K., Naumovski, V., Nammi, S., Chan, K., Roufogalis, B. and Li, G. Herbal medicines and nutraceuticals for diabetic vascular complications: Mechanisms of action and bioactive phytochemicals. Current Pharmaceutical Design 2010; 32.

Nammi, S., Kim, M., Gavande, M., Li, G. and Roufogalis, B. Regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme-A reductase expression by Zingiber officinale in the liver of high-fat diet-fed rats. Basic & Clinical Pharmacology & Toxicology 2010; 7.

2009

Nammi, S., Sreemantula, S. and Roufogalis, B. Protective effects of ethanolic extract of Zingiber officinale rhizome on the development of metabolic syndrome in high fat diet-fed rats. Basic Clin Pharmacol 2009; 8.

2008

Boini, K., Nammi, S., Grahammer, F., Osswald, H., Kuhl, D. and Lang, F. 'Role of serum & glucocorticoid inducible kinase sgk1 in glucocorticoid regulation of renal electrolyte excretion and blood pressure. Kidney and Blood Pressure Research 2008; 10.

2007

Nammi, S., Dembele, K. and Nyomba, B. Increased 11a-hydroxysteroid dehydrogenase type-1 and hexose-6-phosphate dehydrogenase in liver and adipose tissue of rat offspring exposed to alcohol in utero. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2007; 9.

2006

Rexhepaj, F., Grahammer, F., Volkl, H., Remy, C., Wagner, C., Sadulache, D., Artunc, F. and Nammi, S. Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice. FASEB Journal 2006; 9.

Sushruta, K., Satyanarayana, S., Nammi, S. and Rajasekhar, J. Evaluation of the blood-glucose reducing effects of aqueous extracts of the selected umbelliferous fruits used in Culinary Practices. Tropical Journal of Pharmaceutical Research 2006; 5.

Rao, N. and Nammi, S. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats. BMC Complem Altern M 2006.

2005

Sandu, C., Rexhepaj, R., Grahammer, F., Mccormick, J., Henke, G., Palmada, M., Nammi, S. and Lang, U. Decreased intestinal glucose transport in the sgk3-knockout mouse. Pfluger's Archiv European Journal of Physiology 2005; 8.

Nammi, S. Ayurveda and diabetes. Physician's Digest 2005; 7.

Nammi, S., Boini, K., Koppula, S. and Sreemantula, S. Reserpine-induced central effects: Pharmacological evidence for the lack of central effects of Reserpine Methiodide', Canadian Journal of Physiology and Pharmacology 2005; 7.

Sandulache, S., Grahammer, F., Nammi, S., Artunc, F., Mack, A., Huang, D., Vallon, V. and Wulff, P. Renal Ca2+ handling in the sgk1 knockout mouse. Pfluger's Archiv European Journal of Physiology 2005.

Artunc, F., Grahammer, F., Sadulache, D., Bohmer, D., Palmada, M., Henke, G., Nammi, S. and Mack, A. Impaired intestinal amino acid absorption in PDK1 deficient mice. Pflugers Archiv European Journal of Physiology 2005; 1.

Sreemantula, S., Boini, K., Koppula, S., Kilari, E. and Nammi, S. Indirect biochemical evidence that reserpine methiodide produces selective depletion of peripheral biogenic amines in rats. Die Pharmazie 2005; 4.

Sreemantula, S., Nammi, S., Kolanukonda, R., Koppula, S. and Boini, K. Adaptogenic and nootropic activities of aqueous extract of Vitis vinifera (grape seed): An experimental study in rat model. BMC Complem Altern Med 2005.

Rao, P., Nammi, S., Routhu, K. and Raju, A. The antimicrobial activity of Heliotropium indicum Linn. in in vitro assay. Asia Pacific Journal of Pharmacology 2005; 2.

2004

Nalamolu, R., Boini, K. and Nammi, S. Effect of chronic administration of Boerhaavia diffusa Linn. leaf extract on experimental diabetes in rats. Tropical Journal of Pharmaceutical Research 2004; 5.

Rao, N., Annapurna, M., Boini, K. and Nammi, S. Antidiabetic activity of Boerhaavia diffusa L. leaf extract in streptozotocin-induced IDDM model rats. Asia Pacific Journal of Pacific Journal of Pharmacology 2004; 4.

Sreemantula, S., Boini, K. and Nammi, S. Reserpine methonitrate, a novel quaternary analogue of reserpine augments urinary excretion of VMA and 5-HIAA without affecting HVA in rats. BMC Pharmacology 2004.

Satyanarayana, S., Sushruta, K., Sarma, G., Nammi, S. and Subbaraju, G. Antioxidant activity of the aqueous extracts of spicy food additives - evaluation and comparison with ascorbic acid in in-vitro systems. Journal of Herbal Pharmacotherapy 2004; 10.

Nammi, S., Boini, K., Kilari, E. and Sreemantula, S. Pharmacological evidence for lack of central effects of reserpine methonitrate: A novel quaternary analog of reserpine. Therapy 2004; 9.

Birka, C., Krikov, M., Huber, S., Wieder, T., Lang, F., Lang, P., Kempe, D., Hoefling, L., Tanneur, V., Duranton, C., Nammi, S., Henke, G. and Myssina, S. Enhanced susceptibility of erythrocyte apoptosis following phosphate depletion. Pfluger's Archiv European Journal of Physiology 2004; 7.

Nammi, S., Koka, S., Chinnala, K. and Boini, K. Obesity: An overview on its current perspectives and treatment options. Nutrition Journal 2004; 1.

Krishna, M., Nammi, S., Kota, M., Rao, N., Rao, R. and Annapurna, A. Evaluation of hypoglycemic and antihyperglycemic effects of Datura metel (Linn.) seeds in normal and alloxan-induced diabetic rats. J Ethnopharmacol 2004; 4.

Sudhakar, M., Rao, C., Rao, A., Ramesh, A., Nammi, S., Raju, D. and Krishna, M. Antinociceptive and anti-inflammatory effects of the standardized oil of Indian Callistemon tanceolatus leaves in experimental animals. East Central African Journal of Pharmaceutical Sciences 2004; 7.

2003

Satyanarayana, S., Sarma, G., Ramesh, A., Sushruta, K. and Nammi, S. 'Evaluation of herbal preparations for hypoglycemic activity in normal and diabetic rabbits. Pharmaceutical Biology 2003; 7.

Nammi, S., Gudavalli, R., Babu, B., Lodagala, D. and Boini, K. Possible mechanisms of hypotension produced by 70% alcoholic extract of Terminalia arjuna in anaesthetized dogs. BMC Complem Altern M 2003.

Nammi, S., Boini, K., Lodagala, D. and Babu, B. The juice of fresh leaves of Catharanthus roseus Linn. reduces blood flucose in normal and alloxan diabetic rabbits. BMC Complem Altern M 2003.

Nammi, S., Ganti, S., Lodagala, D. and Babu, B. Hypoglycemic and insulin release effects of Hugonia mystax in rabbits. Asia Pacific Journal of Pharmacology 2003; 3.

2002

Rao, P., Babu, D., Rao, R. and Nammi, S. Comparative study of sweet and bitter varieties of Aegle marmelos (L.) Correa for hypoglycemic activity in rabbits. Journal of Natural Remedies 2002; 4.

Rao, P., Nammi, S. and Raju, A. Studies on the antimicrobial activity of Heliotropium indicum. Journal of Natural Remedies 2002; 4

2001

Nammi, S., Ganti, S. and Lodagala, D. Hypoglycemic effect of Aegle marmelos leaf extract on normal and diabetic model rabbits. Asia Pacific Journal of Pharmacology 2001; 3.

Conferences

Kam K, Li KM, Razmovski-Naumovski V, Nammi S, Chan K, Li GQ. Gallic acid prevented endothelial injury by restoring DNMT1 depletion in EAhy926 and HBEC-5i cells (poster).  Annual Meeting of the Consortium for Globalisation of Chinese Medicine; 27-29 August, 2013; Graz, Austria 2013.

Kam A, Li KM, Razmovski-Naumovski V, Nammi S, Chan K, Li G. Multivariant analyses of the geographical variability in the polyphenolic content and antioxidant capacities of pomegranate peel.  2nd Annual Meeting of The Good Practice in TCM Research (GPTCM) Association "TCM Research in Europe - opportunities and challenges"; 30 August, 2013; Graz, Austria 2013.

Kam A, Li KM, Razmovski-Naumovski V, Nammi S, Chan K, Li GQ. Intercontinental variability in the polyphenolic profile and total antioxidant capacity of pomegranate peel (Poster).  11th Annual Oxford International Conference on the Science of Botanicals (ISCB); April 16 -19, 2012; The National Center for Natural Products Research (NCNPR), School of Pharmacy, University of Mississippi, USA. Planta Medica 2012.

Kam A, Li KM, Razmovski-Naumovski V, Nammi S, Chan K, Li G. Protective effects of pomegranate peel against endothelial cell death caused by homocysteine, adenosine and TNF-α (Poster selected for discussion).  11th Meeting of Consortium for Globalization of Chinese Medicine (CGCM); 21-23 August, 2012; Macau, China 2012.

Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G. Good Practice in Traditional Chinese Medicine Research (GP-TCM Congress) in the Post-genomic Era. Leiden, The Netherlands 2012.

Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G.  11th Annual Oxford International Conference on the Science of Botanicals (ICSB) 2012.

Roufogalis, B., Nammi, S., Li, X., Mcgrath, K., Heather, A., Li, Y., Tran, A. and Duke, C. 3rd Australia-China Biomedical Research Conference (ACBRC), Melbourne, Australia 2011.

Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G. International forum on evidence based integration of Traditional Chinese Medicine (TCM) in Australia 2011.

Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G.  Consortium for Globalization of Chinese Medicine (CGCM) 2011.

Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G. Bosch Institute Young Investigators Symposium, Sydney, Australia 2011.

Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G. Australasian Pharmaceutical Science Association (APSA) Annual Conference, Brisbane, Australia 2010.

Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G. (2010), '9th Consortium for Globalization of Chinese Medicine (CGCM)', 9th Consortium for Globalization of Chinese Medicine (CGCM), Hong Kong.

Nammi, S. 1st International Euro-India Conference on Holistic Medicine, Kottayam, India 2008.

Nammi, S. and Roufogalis, B. 3rd International Congress on Complementary Medicine Research, Sydney, Australia 2008.

Friedrich, B., Grahammer, F., Sandulache, D., Artunc, F., Henke, G., Rexhepaj, R., Nammi, S. and Alessi, D. 36th Kongress der Gesellschaft fur Nephrologie, Saarbruken, Germany 2005.

Boini, K., Annapurna, A., Kota, M., Rao, R. and Nammi, S. Proceedings of AP Academy of Sciences 2004.

S, S., Nammi, S. and B, K. 56th Indian Pharmaceutical Congress, Kolkata, India 2004.

Nammi, S., Birka, C., Lang, P., Kempe, D., Hoefling, L., Tanneur, V., Duranton, C. and Henke, G. 83rd Annual Meeting of Deutsche Physiologische Gesellschaft, Leipzig, Germany 2004.

S, S., Nammi, S., K, S. and B, K. 55th Indian Pharmaceutical Congress, Chennai, India 2003.

S, S., Nammi, S. and B, K. National Seminar on Pharmaceutical Research: Present and Future Perspectives, Visakhapatnam, India 2003.

Nammi, S. 54th Indian Pharmaceutical Congress, Pune, India 2002.

Nammi, S. and Koppula, S. Seminar on Pharmaceutical Research in the New Millennium, Visakhapatnam, India 2002.

Koppula, S. and Nammi, S. Seminar on Pharmaceutical Research in the New Millennium, Visakhapatnam, India 2002.

Nammi, S. and Ganti, S. Seminar on Pharmaceutical Research in the New Millennium, Visakhapatnam, India 2002.

Nammi, S. and S, S. Dr. KV Rao Scientific Society, Hyderabad, India 2002.

Nammi, S., D, M. and S, S. 53rd Indian Pharmaceutical Congress, New Delhi, India 2001.

Nammi, S. and S, S. Seminar on Evaluation of Herbal Antidiabetic Drugs, Chennai, India 2001.

Annapurna, A., Kumar, K., Rambabu, G. and Nammi, S. Ceramide: A novel second messenger. Proceedings of Indian National Science Academy, 10.