Joelle Metri

Investigating a sustainable means of monitoring alzheimer’s disease risk via non-invasive biomarkers

This MRes project aims to investigate the relationship between the kynurenine pathway and Alzheimer’s disease. This project will assess samples from healthy adults, as well as adults at risk of Alzheimer's disease using established analytical methods and statistical modelling.

This project will identify validated analytical methods for the identification and quantification of key kynurenine pathway metabolites and use these to quantify key kynurenine pathway metabolites in samples from healthy younger adults. This data will then be compared to samples of older adults who are at-risk or not-at-risk of Alzheimer’s disease. These findings will help to elucidate the relationship between the kynurenine pathway and Alzheimer’s disease, with findings furthering research to help diagnose Alzheimer's disease and it's early detection.

Supervisors:

Associate Professor Genevieve Steiner-Lim, Dr Mitchell Low, Dr Chai K. Lim